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In a randomized, double-blind trial where women applied GHK-Cu encapsulated in a nano-lipid carrier twice daily for 8 weeks, the treatment group saw significant improvements in wrinkle depth and volume with no serious adverse events
28 No significant changes were seen in nevi on the body
We reasoned these differences result from changes in the R-domain position or conformation in a phosphorylation-dependent manner similar to CFTR 25 but note that the phosphates themselves may block protease accessibility to some sites as well
& Ciurtin, C
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